SBCN 2018 Programm

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  • Monday 14 May
    Day 1
  • Tuesday 15 May
    Day 2
  • Wednesday 16 May
    Day 3
  • Thursday 17 May
    Day 4
  • Launch
  • Session 1: Proteins Purification 1
12:30 - 14:00 Registration and lunch

14:00 - 14:15 Welcome
Véronique PALLET- Vice President Researcher & Transfer of Bordeaux INP

Opening :
Xavier SANTARELLI, Symposium Chairperson
M.A.VIJAYALAKSHMI, Symposium Co-Chairperson

14:30 - 15:15 PL.1.
Inaugural Plenary Lecture: Applying old know how to new challenges: the manufacturing of emerging therapeutic modalities.

Dr. Uwe GOTTSCHALK, CSO Lonza Pharma Biotech, LONZA AG, Basel, Switzerland

15:20 - 16:10 PL.2.
High Throughput Process Development for the Purification of Proteins.

Professor Marcel OTTENS, Delft University of Technology, Delft, Netherlands

Coffee break & Posters Session & Exhibitions

16:30 - 16:40 MabSelect™ PrismA, the next-generation Protein A resin for improved productivity and bioburden control.
The next-generation Protein A resin for improved productivity and bioburden control.

Laure Marmin GE Healthcare Lifesciences France

16:40-17:00 C1
Dual screening for purification process development.

Carole AVIAS, Kévin Edjaga, Christelle Sihabout, Merck Biodevelopment, 1 rue Jacques Monod, 33650 Martillac, France

17:00 - 17:20 C2
Multicriteria optimization of rapeseed protein extraction and purification.

Claire DEFAIX, Sara Albe Slabi, Mélody Basselin, Odile Mesières, Arnaud Aymes, Olivier Galet, Frantz Fournier, Romain Kapel, LRGP UMR 7274 ; 13 rue du Bois de la Champelle, 54500 Vandoeuvre-lès-Nancy, France

17h20 - 17h40 C3
Selective Extraction and Activity Guided Integrated Purification of Gamma-Conglutin from Lupin Seeds for Management of Type-II Diabetes.

Naina N. SINGH, Snehal Agrawal and Sandeep B. Kale Institute of Chemical Technology (ICT), NM Parikh Marg, Matunga East, Mumbai-400019, INDIA

17:40 - 18:00 C4
Recombinant Production, Isotopic Labeling, Purification and Three-Dimensional NMR Solution Structure of the Proapoptotic Death Receptor DR5 complexed to Peptidomimetic Ligands of TRAIL.

Antoine BAUDIN 1, Anne Guichard1, Stéphane Chaignepain1, Agnès Hocquellet1, Cameron Mackereth2, Gilles Guichard1, Benoit Odaert1 1 - Institute of Chemistry and Biology of Membranes and Nanoobjects, UMR 5248 2 - Univ. Bordeaux, Institut Européen de Chimie et Biologie, INSERM 1212, ARNA laboratory, Bordeaux, France

  • Session 2: Peptides, Proteins and other molecules Analysis
  • Session 3: Proteins purification 2
9:00 - 9:40 PL.3.
Capillary electrophoresis a powerful nanoseparation technique for the analysis of peptide and protein Biomarkers.

Myriam TAVERNA, Université Paris Sud, Paris, France

9:45 - 10:20 SL1
Online Four-Dimensional HIC x SEC-IM-MS Methodology for Characterization of Antibody Drug Conjugates.

Valentina D‘ATRI, University of Geneva, CMU, Geneva, Switzerland

10:20 - 10:40 C5
Analysis and characterization of lipid Antisens Oligonucleotides (LASO) as promising therapeutic agents.

Fatima BARAKAT, Ludivine Ferey, Brune Vialet, Sébastien Benizri, Philippe Barthélémy, Karen Gaudin, ARNA INSERM U1212 UMR CNRS 5320 Université Bordeaux, Bordeaux, France

10:20 - 10:30 Fractionation and characterization of proteins or other biomacromolecules and nanoparticles.

Stéphanie TERME, WYATT Technology France

Coffee break & Posters Session & Exhibitions

11:00 - 11:50 PL.4.
Advanced analytical methodologies for multiresidue control of chemical hazardous agents in foods.

Professor Ana Maria GARCIA CAMPAÑA, Director of Department Analytical Chemistry, University of Granada, Granada, Spain

12:00 - 12:20 C6
Development of new SE-HPLC method for simultaneous quantification of proteins and phenolic compounds from oleaginous meal.

Sara Albe Slabi 1,2,3, Christelle Mathé 1,2, Arnaud Aymes 1,2, Xavier Framboisier1,2, Olivier Galet3, Kapel Romain 1,2 1 - Laboratoire Réaction et Génie des Procédés, UMR-7274, 2 - Université de Lorraine, 3 - Avril SCA, Nancy, France

12:20 - 12:40 C7
Use of GC/GC-MS and GC-MS/MS to identify and quantitate new aromatic compounds associated to hazelnut notes of great Chardonnay wines.

Marine GAMMACURTA, Jacques Gros, Cécile Thibon, Valérie Lavigne, Denis Dubourdieu, Philippe Darriet, and Axel Marchal. ISVV, Univ. de Bordeaux, 210 chemin de Leysotte, 33882 Villenave d’Ornon, France

12:40 - 13:00 C8
Characterization of steroids in terms of collision cross section (CCS) by ion mobility spectrometry and its potential applications in steroidomics.

Maykel HERNÁNDEZ-MESA†, Ana M. García-Campaña‡, Fabrice Monteau†, Bruno Le Bizec†, Gaud Dervilly-Pinel† † - Laboratoire d’Etude des Résidus et Contaminants dans les Aliments (LABERCA), Oniris, INRA UMR 1329, UBL, Nantes F-44307, France ‡ - Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Av. Fuentenueva s/n, Granada E-18071, Spain

Lunch & Posters Session & Exhibitions

13:45 - 14:35 PL.5.
Application of molecularly imprinted polymers for one-step purifications of proteins.

Professor Leif BÜLOW, Lund University, Lund, Sweden

14:35 - 14:55 C9
Continuous antibody precipitate harvest by two-stage tangential flow filtration

Daniel BURGSTALLER, Peter Satzer, Alois Jungbauer
University of Natural Resources and Life Sciences, Vienna; Department of Biotechnology, Muthgasse 18; 1190 Vienna, Austria

15:00 - 15:20 C10
Efficient new lectin-based affinity tag allowing simple, safe and low-cost recombinant protein purification.

Alexandre KRIZNIK, Mélissa YELEHE OKOUMA, Christophe CHARRON, Hortense MAZON, Hélène LE CORDIER, Guillaume GROSHENRY, Sandrine BOSCHI-MULLER, Jean-Yves JOUZEAU and Pascal REBOUL.
UMR 7365 IMoPA CNRS-Université de Lorraine, Département de Pharmacologie Clinique et Toxicologie, Centre Hospitalier Régional Universitaire, Nancy. Biopôle de l’Université de Lorraine - Campus biologie-santé, 9, Avenue de la Forêt de Haye - B.P. 20199, 54505 Vandœuvre-lès-Nancy cedex, France

15:20 - 15:30 Biorad: Unique Functionalities to Purify Challenging Molecules

15:30 - 15:50 C11
Production, purification and characterization of a new bilirubin oxidase.

Claire STINES-CHAUMEIL, Elodie ROUSSARIE, Iman TRABOULSI, Yousefian NAREK, Sébastien GOUNEL, Emmanuel SURANITI, Nicolas MANO Université de Bordeaux, Centre de Recherche Paul Pascal (UMR 5031), 115 Avenue Albert Schweitzer 33600 Pessac, France.

15:50 - 16:00 Latest innovations added to Pall portfolio applied to mAb purification in batch or continuous mode

Catherine ALLIOUX, Global product manager Chromatography Sorbent & Membrane Pall Biotech

16:00 - 16:20 C12
Simultaneous quantification of hydrolysis degree, protein conversion rate and mean weight of peptides released during enzymatic proteolysis.


Coffee break & Posters Session & Exhibitions

16:45 - 18:30 Workshop

Enabling the Next Generation Bioprocessing Paradigm,
Claudia Di Toma, Technology Manager, Merck Life Science  

Evolution of modern chromatography solution, new resins and systems
Laure Marmin & Jean-Philippe Boursier, GE Healthcare Lifesciences, France  

Mixed-Mode Chromatography – New Technologies and Case Studies
Carsten Voss, Bio-Rad  

Rapid Process Development Strategy for Optimizing mAbs purification- Transfer from batch to continuous mode.
Catherine ALLIOUX, Global product manager Chromatography Sorbent & Membrane  Pall Biotech
Integration of ILC (In Line Concentration), ILDF ( In line Diafiltration) in a continuous bioprocessing.
Estelle TRAN, Pall Biotech  

  • Session 4: Process
  • Session 5: Biochromatography
  • SBCN 2018 Gala Dinner
8:30 - 9:25 PL.6.
Improving the performance of process chromatography of biologics by using simplified mechanistic models -Yamamoto models for process design, understanding and analysis.

Professor Shuichi YAMAMOTO, Yamaguchi University, Ube, Japan

9:25 - 9:50 C13
A Rational Approach for Comparing Different Affinity Chromatographic Processes for the Capture of Monoclonal Antibodies.

Laurent DAVID, Ypso-Facto, Nancy, France

9:50 - 10:15 C14
Impact of the buffer modifications in the Chelating Affinity Chromatography in EPOCIM production at industrial scale.

Rosario MARTINEZ, Aliuska Cardoso, Aymara Nieto, Liriaude Diaz, Anelis Quintana and Yanet Borrego. Molecular Immunology Center (CIM), Havana, Cuba

10:15 - 10:50 SKN1
Modular Membrane Adsorber Cassettes for Virus Capture and Sterile Chromatography.

Stefan FISCHER-FRÜHHOLZ, Sartorius Stedim Biotech , Germany

10:50 - 11:00 Introduction to Natrix Separations

Matthieu MIESCH, Chromatography Sales Specialist, Merck Life Science

Coffee break & Poster session

11:30 - 12:15 PL.7.
New developments in countercurrent protein purification: optimisation and failure-mode detection.

Professor Ajoy VELAYUDHAN, Department of Biochemical Engineering, University College London, United Kingdom

12:15 - 12:40 C15
Comprehensive experimental characterization of the MCSGP process.

Sebastian VOGG, Nicole Ulmer, Massimo Morbidelli. ETH Zürich, Vladimir-Prelog-Weg 1, 8093 Zurich, Switzerland

12:40 - 13:00 C16
Real-time prediction of quantity, purity and impurities during antibody capture.

Nicole WALCH, Dominik Sauer, Edit Felföldi, Theresa Scharl-Hirsch, Michael Melcher, Friedrich Leisch, Alois Jungbauer, Astrid Dürauer Acib GmbH, Muthgasse 18, 1190 Vienna, Austria

Lunch & Posters Session & Exhibitions

14:00 - 14:50 PL8
Estimation of structural and chromatographic properties from a pressure drop data.

Professor Aleš PODGORNIK, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Slovenia

14:50 - 15:15 C17
Thermosensitivity of Protein A Affinity Media.

Walpurga KREPPER, Peter Satzer, Beate Maria BEYER and Alois Jungbauer University of Natural Resources and Life Sciences, Department of Biotechnology, Muthgasse 11, 1190 Vienna, Austria

15:20 - 15:50 SL2
Aptamers: Powerful and Innovative Ligands in Affinity Chromatography.

Gerald PERRET, Ph.D. Projects Director - Therapeutic Innovation Department, LFB, Les Ulis, France

15:50 - 16:15 A New Depletion Technology for Purification Operations : DAISEP MabXpure
A New Depletion Technology for Purification Operations : DAISEP MabXpure

(Case Study by SANOFI) F. Rousset (DAICEL Bioseparations – Chiral Tech. EU) / C.Coquan (Sanofi)

16:15-16:35 C18
Purification of Hsp12 from Saccharomyces cerevisiae using mixed mode chromatography

Antoine Léger 1, V. Moine 2, AXel. Marchal 3 and Charlotte Cabanne 1 1. Bordeaux INP, CBMN, Equipe SAMB, UMR 5248, F-33600, Pessac, France 2. Biolaffort, 126 quai de la Souys, F-33100 Bordeaux, France 3. ISVV, 210, chemin de Leysotte CS 50008 F-33882 Villenave d'Ornon, France

16:35 - 16h45 Latest innovations added to Pall portfolio applied to mAb purification in batch or continuous mode
Latest innovations added to Pall portfolio applied to mAb purification in batch or continuous mode

Catherine ALLIOUX, Global product manager Chromatography Sorbent & Membrane Pall Biotech

Coffee break & Posters Session & Exhibitions

17:15 - 18:15 Studying membrane protein function using SEC* CorA ion channel

Jon LUNDQVIST PhD and R&D Scientist at GE Healthcare Lifesciences, Sweden

SBCN 2018 Gala Diner - Cité Mondiale

Access : tramway line B – CAPC Musée d'Art Contemporain Station

  • Session 6
9:00 - 9:50 PL9
Hollow fiber fff for macromolecules and nano particles aggregates as well as degradation products assessments.

Professor Philippe CARDOT, Limoges University, Limoges, France C.Lefort, Marc Mongy, Tayssir Ibrahim, Gaelle bégaud, PhiIippe CARDOT

10:25 - 10:55 SL3
Tandem Column Adsorption with Solvent Recycle Coupled with Kinetic Chromatographic Purification of Vancomycin B.

Shreyas tribhuwane, Anand Gupta, Naina N. Singh and Sandeep B. KALE* Institute of Chemical Technology (ICT), NM Parikh Marg, Matunga East, Mumbai-400019, INDIA

09:50 - 10:25 C20
Field flow fractionation techniques: powerful tools for the characterization of biomolecules.

Estelle N’tsiba, Marie Hennetier, Audrey Ric, Frédéric Violleau Plateforme Toulouse Field-Flow Fractionnement Center (TFFFC) Ecole d’Ingénieurs de Purpan, 75 voie du TOEC, 31076 Toulouse Cedex 3

Coffee break & Poster Session & Exhibition

11:25 - 11:45 C21
Enzyme-Ligand binding analysis by the chromatographic method of Hummel and Dreyer.

Jean Chaudière, Bordeaux University, CBMN, Equipe SAMB, UMR 5248, F-33600, Pessac, France

11:45 - 12:15 International bioseparation contest for young scientists 2012


12:15 - 12:30 Conclusion